Atypical infections Chronic granulomatous disease

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microscopic image of fungus, aspergillus fumigatus, organism commonly causes disease in people chronic granulomatous disease.


people cgd infected organisms not cause disease in people normal immune systems. among common organisms cause disease in cgd patients are:



bacteria (particularly catalase-positive)

staphylococcus aureus.
serratia marcescens.
listeria species.
e. coli.
klebsiella species.
pseudomonas cepacia, a.k.a. burkholderia cepacia.
nocardia.


fungi

aspergillus species. aspergillus has propensity cause infection in people cgd , of aspergillus species, aspergillus fumigatus seems common in cgd.
candida species.



patients cgd can resist infections of catalase-negative bacteria susceptible catalase-positive bacteria. catalase enzyme catalyzes breakdown of hydrogen peroxide in many organisms. in infections caused organisms lack catalase (catalase-negative), host cgd able borrow hydrogen peroxide being made organism , use fight off infection. in infections organisms have catalase (catalase-positive), borrowing mechanism unsuccessful because catalase enzyme first breaks down hydrogen peroxide borrowed organism. therefore in cgd patient, hydrogen peroxide cannot used make oxygen radicals fight infection, leaving patient vulnerable infection catalase-positive bacteria.








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